TY - JOUR
T1 - Trends in bone marrow sampling and core biopsy specimen adequacy in the United States and Canada
T2 - A multicenter study
AU - Merzianu, Mihai
AU - Groman, Adrienne
AU - Hutson, Alan
AU - Cotta, Claudiu
AU - Brynes, Russell K.
AU - Orazi, Attilio
AU - Reddy, Vishnu
AU - Teruya-Feldstein, Julie
AU - Amre, Ramila
AU - Balasubramanian, Manjula
AU - Brandao, Guilherme
AU - Cherian, Sindhu
AU - Courville, Elizabeth
AU - Czuchlewski, David
AU - Fan, Guang
AU - Grier, David
AU - Hoehn, Daniela
AU - Inamdar, Kedar V.
AU - Juskevicius, Ridas
AU - Kaur, Prabhjot
AU - Lazarchick, John
AU - Lewis, Michael R.
AU - Miles, Rodney R.
AU - Myers, Jerome B.
AU - Nasr, Michel R.
AU - Qureishi, Hina N.
AU - Olteanu, Horatiu
AU - Robu, Valentin G.
AU - Salaru, Gratian
AU - Vajpayee, Neerja
AU - Vos, Jeffrey
AU - Zhang, Ling
AU - Zhang, Shanxiang
AU - Aye, Le
AU - Brega, Elisa
AU - Coad, James E.
AU - Grantham, John
AU - Ivelja, Sinisa
AU - McKenna, Robert
AU - Sultan, Kieran
AU - Wilding, Gregory
AU - Hutchison, Robert
AU - Peterson, Loann
AU - Cheney, Richard T.
N1 - Publisher Copyright: © 2018 American Society for Clinical Pathology. All rights reserved.
PY - 2018/10/1
Y1 - 2018/10/1
N2 - Objectives: To assess bone marrow (BM) sampling in academic medical centers. Methods: Data from 6,374 BM samples obtained in 32 centers in 2001 and 2011, including core length (CL), were analyzed. Results: BM included a biopsy (BMB; 93%) specimen, aspirate (BMA; 92%) specimen, or both (83%). The median (SD) CL was 12 (8.5) mm, and evaluable marrow was 9 (7.6) mm. Tissue contraction due to processing was 15%. BMB specimens were longer in adults younger than 60 years, men, and bilateral, staging, and baseline samples. Only 4% of BMB and 2% of BMB/BMA samples were deemed inadequate for diagnosis. BM for plasma cell dyscrasias, nonphysician operators, and ancillary studies usage increased, while bilateral sampling decreased over the decade. BM-related quality assurance programs are infrequent. Conclusions: CL is shorter than recommended and varies with patient age and sex, clinical circumstances, and center experience. While pathologists render diagnoses on most cases irrespective of CL, BMB yield improvement is desirable.
AB - Objectives: To assess bone marrow (BM) sampling in academic medical centers. Methods: Data from 6,374 BM samples obtained in 32 centers in 2001 and 2011, including core length (CL), were analyzed. Results: BM included a biopsy (BMB; 93%) specimen, aspirate (BMA; 92%) specimen, or both (83%). The median (SD) CL was 12 (8.5) mm, and evaluable marrow was 9 (7.6) mm. Tissue contraction due to processing was 15%. BMB specimens were longer in adults younger than 60 years, men, and bilateral, staging, and baseline samples. Only 4% of BMB and 2% of BMB/BMA samples were deemed inadequate for diagnosis. BM for plasma cell dyscrasias, nonphysician operators, and ancillary studies usage increased, while bilateral sampling decreased over the decade. BM-related quality assurance programs are infrequent. Conclusions: CL is shorter than recommended and varies with patient age and sex, clinical circumstances, and center experience. While pathologists render diagnoses on most cases irrespective of CL, BMB yield improvement is desirable.
KW - Bone marrow adequacy
KW - Bone marrow biopsy
KW - Bone marrow biopsy indications
KW - Bone marrow quality
KW - Core biopsy length
UR - http://www.scopus.com/inward/record.url?scp=85054058210&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85054058210&partnerID=8YFLogxK
U2 - 10.1093/ajcp/aqy066
DO - 10.1093/ajcp/aqy066
M3 - Article
C2 - 30052721
SN - 0002-9173
VL - 150
SP - 393
EP - 405
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 5
ER -