Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes

Mark Rabin, Charles P. Hart, Anne Ferguson-Smith, William McGinnis, Michael Steven Levine, Frank H. Ruddle

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The homoeo box is a 180-base pair (bp) DNA sequence conserved in Drosophila homoeotic genes, which regulate early development1,2. These DNA sequences are present in open reading frames and have been identified in specific gene transcripts in Drosophila and Xenopus embryos3-5; they possess structural features in common with genes encoding some DNA-binding proteins6,7. Homologous homoeo box sequences have been detected in species ranging from insects and annelids to vertebrates2,5,8. The high degree of sequence conservation (70-90%) among different species suggests a strong evolutionary relationship and implies a common role in embryonic development. To test this hypothesis, one approach we have used is to examine the patterns of genetic organization of homoeo box sequences in mouse and human for any similarities; the second approach is to localize the chromosomal map positions of homoeo box sequences in the two species. A similar genomic organization and chromosomal distribution of homoeo box sequences would argue for a conserved function and might shed light on their mechanism of action. Here, we describe experiments which show that two homoeo box loci map, respectively, to evolutionarily related regions on mouse chromosome 11 and human chromosome 17.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalNature
Volume314
Issue number6007
DOIs
StatePublished - Dec 1 1985

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Human Chromosomes
Drosophila
Genes
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 17
Xenopus
Base Pairing
Open Reading Frames
Embryonic Development
Insects
DNA

All Science Journal Classification (ASJC) codes

  • General

Cite this

Rabin, M., Hart, C. P., Ferguson-Smith, A., McGinnis, W., Levine, M. S., & Ruddle, F. H. (1985). Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes. Nature, 314(6007), 175-178. https://doi.org/10.1038/314175a0
Rabin, Mark ; Hart, Charles P. ; Ferguson-Smith, Anne ; McGinnis, William ; Levine, Michael Steven ; Ruddle, Frank H. / Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes. In: Nature. 1985 ; Vol. 314, No. 6007. pp. 175-178.
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Rabin, M, Hart, CP, Ferguson-Smith, A, McGinnis, W, Levine, MS & Ruddle, FH 1985, 'Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes', Nature, vol. 314, no. 6007, pp. 175-178. https://doi.org/10.1038/314175a0

Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes. / Rabin, Mark; Hart, Charles P.; Ferguson-Smith, Anne; McGinnis, William; Levine, Michael Steven; Ruddle, Frank H.

In: Nature, Vol. 314, No. 6007, 01.12.1985, p. 175-178.

Research output: Contribution to journalArticle

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Rabin M, Hart CP, Ferguson-Smith A, McGinnis W, Levine MS, Ruddle FH. Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes. Nature. 1985 Dec 1;314(6007):175-178. https://doi.org/10.1038/314175a0