Two-in-one

Combined targeted chemo and gene therapy for tumor suppression and prevention of metastases

Min Zhang, Olga B. Garbuzenko, Kenneth Reuhl, Lorna Rodriguez-Rust, Tamara Minko

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Aims: To develop an approach for the effective treatment of ovarian tumor, prevention of metastases and limitation of side effects. Materials & Methods: In order to combine chemotherapy with genotherapy, we constructed a nanoscale-based tumor-targeted system containing two anticancer drugs, two antisense oligonucleotides (suppressors of cellular resistance) and a ligand specific to receptors overexpressed in cancer cells. The system was tested in a mouse metastatic xenograft model using tumor isolates from patients with ovarian carcinoma. Results: Treatment with the proposed nanosystem decreased primary tumor, prevented intraperitoneal metastases and limited adverse side effects. Conclusions: The advantages of the proposed targeted complex treatment of primary aggressive ovarian tumor and prevention of metastases make the proposed approach promising for clinical applications.

Original languageEnglish (US)
Pages (from-to)185-197
Number of pages13
JournalNanomedicine
Volume7
Issue number2
DOIs
StatePublished - Feb 1 2012

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Gene therapy
Chemotherapy
Genetic Therapy
Tumors
Neoplasm Metastasis
Neoplasms
Nanosystems
Antisense Oligonucleotides
Oligonucleotides
Heterografts
Ligands
Cells
Therapeutics
Carcinoma
Drug Therapy
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Materials Science(all)
  • Biomedical Engineering
  • Medicine (miscellaneous)

Cite this

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Two-in-one : Combined targeted chemo and gene therapy for tumor suppression and prevention of metastases. / Zhang, Min; Garbuzenko, Olga B.; Reuhl, Kenneth; Rodriguez-Rust, Lorna; Minko, Tamara.

In: Nanomedicine, Vol. 7, No. 2, 01.02.2012, p. 185-197.

Research output: Contribution to journalArticle

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