Ultrasonic relaxation and1H NMR evidence demonstrating that urea destacks 6-methylpurine aggregates

Paul Hemmes; Leslie Oppenheimer; Robert Rhinesmith; Gloria Anderte; David Saar; Frank Jordan

doi:10.1021/j100445a024

Ultrasonic relaxation and¹H NMR evidence demonstrating that urea destacks 6-methylpurine aggregates

Paul Hemmes
, Leslie Oppenheimer
, Robert Rhinesmith
, Gloria Anderte
, David Saar
, Frank Jordan

Rutgers Newark, Chemistry

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The ultrasonic relaxation behavior of 0.075 M 6-methylpurine was investigated in detail in water-urea mixtures ranging from 0 to 7 M urea. The concentration-dependent ultrasonic relaxation, presumably due to the intermolecular stacking association process, decreases in magnitude but occurs at nearly the same frequency in the entire range of solvent mixtures employed. Since it was previously shown that the glycosyl isomerization and stacking processes are coupled in nucleosides and nucleotides, it is proposed that 7 M urea be employed in demonstration of intrinsic glycosyl isomerization kinetics and thermodynamics. ¹H NMR studies support the ultrasonic relaxation results.

Original language	American English
Pages (from-to)	911-913
Number of pages	3
Journal	Journal of physical chemistry
Volume	84
Issue number	8
DOIs	https://doi.org/10.1021/j100445a024
State	Published - 1980

ASJC Scopus subject areas

General Engineering
Physical and Theoretical Chemistry

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10.1021/j100445a024

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abstract = "The ultrasonic relaxation behavior of 0.075 M 6-methylpurine was investigated in detail in water-urea mixtures ranging from 0 to 7 M urea. The concentration-dependent ultrasonic relaxation, presumably due to the intermolecular stacking association process, decreases in magnitude but occurs at nearly the same frequency in the entire range of solvent mixtures employed. Since it was previously shown that the glycosyl isomerization and stacking processes are coupled in nucleosides and nucleotides, it is proposed that 7 M urea be employed in demonstration of intrinsic glycosyl isomerization kinetics and thermodynamics. 1H NMR studies support the ultrasonic relaxation results.",

author = "Paul Hemmes and Leslie Oppenheimer and Robert Rhinesmith and Gloria Anderte and David Saar and Frank Jordan",

year = "1980",

doi = "10.1021/j100445a024",

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volume = "84",

pages = "911--913",

journal = "Journal of physical chemistry",

issn = "0022-3654",

publisher = "American Chemical Society",

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T1 - Ultrasonic relaxation and1H NMR evidence demonstrating that urea destacks 6-methylpurine aggregates

AU - Hemmes, Paul

AU - Oppenheimer, Leslie

AU - Rhinesmith, Robert

AU - Anderte, Gloria

AU - Saar, David

AU - Jordan, Frank

PY - 1980

Y1 - 1980

N2 - The ultrasonic relaxation behavior of 0.075 M 6-methylpurine was investigated in detail in water-urea mixtures ranging from 0 to 7 M urea. The concentration-dependent ultrasonic relaxation, presumably due to the intermolecular stacking association process, decreases in magnitude but occurs at nearly the same frequency in the entire range of solvent mixtures employed. Since it was previously shown that the glycosyl isomerization and stacking processes are coupled in nucleosides and nucleotides, it is proposed that 7 M urea be employed in demonstration of intrinsic glycosyl isomerization kinetics and thermodynamics. 1H NMR studies support the ultrasonic relaxation results.

AB - The ultrasonic relaxation behavior of 0.075 M 6-methylpurine was investigated in detail in water-urea mixtures ranging from 0 to 7 M urea. The concentration-dependent ultrasonic relaxation, presumably due to the intermolecular stacking association process, decreases in magnitude but occurs at nearly the same frequency in the entire range of solvent mixtures employed. Since it was previously shown that the glycosyl isomerization and stacking processes are coupled in nucleosides and nucleotides, it is proposed that 7 M urea be employed in demonstration of intrinsic glycosyl isomerization kinetics and thermodynamics. 1H NMR studies support the ultrasonic relaxation results.

UR - https://www.scopus.com/pages/publications/1842420856

UR - https://www.scopus.com/pages/publications/1842420856#tab=citedBy

U2 - 10.1021/j100445a024

DO - 10.1021/j100445a024

M3 - Article

SN - 0022-3654

VL - 84

SP - 911

EP - 913

JO - Journal of physical chemistry

JF - Journal of physical chemistry

IS - 8

ER -

Ultrasonic relaxation and¹H NMR evidence demonstrating that urea destacks 6-methylpurine aggregates

Abstract

ASJC Scopus subject areas

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