Understanding physiology in the continuum: Integration of information from multiple -omics levels

Kubra Kamisoglu, Alison Acevedo, Richard R. Almon, Susette Coyle, Siobhan Corbett, Debra C. Dubois, Tung T. Nguyen, William J. Jusko, Ioannis P. Androulakis

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

In this paper, we discuss approaches for integrating biological information reflecting diverse physiologic levels. In particular, we explore statistical and model-based methods for integrating transcriptomic, proteomic and metabolomics data. Our case studies reflect responses to a systemic inflammatory stimulus and in response to an anti-inflammatory treatment. Our paper serves partly as a review of existing methods and partly as a means to demonstrate, using case studies related to human endotoxemia and response to methylprednisolone (MPL) treatment, how specific questions may require specific methods, thus emphasizing the non-uniqueness of the approaches. Finally, we explore novel ways for integrating -omics information with PKPD models, toward the development of more integrated pharmacology models.

Original languageEnglish (US)
Article number91
JournalFrontiers in Pharmacology
Volume8
Issue numberFEB
DOIs
StatePublished - Feb 27 2017

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Keywords

  • Glucocorticoids
  • Inflammation
  • LPS
  • Metabolomics
  • Pharmacogenomics
  • Proteomics
  • Transcriptomics

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