Updated mechanisms underlying sickle cell disease-associated pain

TY - JOUR

T1 - Updated mechanisms underlying sickle cell disease-associated pain

AU - Du, Shibin

AU - Lin, Corinna

AU - Tao, Yuan Xiang

N1 - Funding Information: This work was supported by USA National Institutes of Health ( NIH ) grants ( R01NS094664 , R01NS094224 and R01NS111553 ) to Y.X.T. Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Sickle cell disease (SCD) is one of the most common severe genetic diseases around the world. A majority of SCD patients experience intense pain, leading to hospitalization, and poor quality of life. Opioids form the bedrock of pain management, but their long-term use is associated with severe side effects including hyperalgesia, tolerance and addiction. Recently, excellent research has shown some new potential mechanisms that underlie SCD-associated pain. This review focused on how transient receptor potential vanilloid 1, endothelin-1/endothelin type A receptor, and cannabinoid receptors contributed to the pathophysiology of SCD-associated pain. Understanding these mechanisms may open a new avenue in managing SCD-associated pain and improving quality of life for SCD patients.

AB - Sickle cell disease (SCD) is one of the most common severe genetic diseases around the world. A majority of SCD patients experience intense pain, leading to hospitalization, and poor quality of life. Opioids form the bedrock of pain management, but their long-term use is associated with severe side effects including hyperalgesia, tolerance and addiction. Recently, excellent research has shown some new potential mechanisms that underlie SCD-associated pain. This review focused on how transient receptor potential vanilloid 1, endothelin-1/endothelin type A receptor, and cannabinoid receptors contributed to the pathophysiology of SCD-associated pain. Understanding these mechanisms may open a new avenue in managing SCD-associated pain and improving quality of life for SCD patients.

KW - Cannabinoid receptors

KW - Endothelin type A receptor

KW - Endothelin-1

KW - Pain

KW - Sickle cell disease

KW - TRPV1

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U2 - 10.1016/j.neulet.2019.134471

DO - 10.1016/j.neulet.2019.134471

M3 - Review article

C2 - 31505241

SN - 0304-3940

VL - 712

JO - Neuroscience Letters

JF - Neuroscience Letters

M1 - 134471

ER -