Uric acid in Parkinson's disease

Ilana Schlesinger, Naomi Schlesinger

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

Recent studies have provided evidence that uric acid may play a role in the development and progression of Parkinson's disease (PD). Uric acid is a natural antioxidant that may reduce oxidative stress, a mechanism thought to play a role in the pathogenesis of PD. Higher levels of serum urate (SU) may have a neuroprotective effect. High SU levels reduced the risk of developing PD and correlated with slower PD progression. Among PD patients SU levels were lower as compared with controls. The manipulation of SU levels holds promise in the treatment of PD. It is possible that a high purine diet in patients with PD may slow progression of the disease. Milk and meat consumption as well as exercise modify the risk of developing PD possibly through their influence on SU levels. In this article, we review the association between PD and SU levels and its implication on the management of PD.

Original languageEnglish (US)
Pages (from-to)1653-1657
Number of pages5
JournalMovement Disorders
Volume23
Issue number12
DOIs
StatePublished - Sep 15 2008

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Keywords

  • Neuroprotection
  • Parkinson's disease
  • Urate
  • Uric acid

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