Urinary cell-free microRNA biomarker could discriminate bladder cancer from benign hematuria

Xuan Mei Piao, Pildu Jeong, Ye Hwan Kim, Young Joon Byun, Yanjie Xu, Ho Won Kang, Yun Sok Ha, Won Tae Kim, Jong Young Lee, Seung Hwo Woo, Tae Gyun Kwon, Isaac Y. Kim, Sung Kwon Moon, Yung Hyun Choi, Eun Jong Cha, Seok Joong Yun, Wun Jae Kim

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations


    The most common symptom of bladder cancer (BC) is hematuria. However, not all patients with hematuria are diagnosed with BC. Here, we explored a novel method to discriminate BC from hematuria under nonmalignant conditions by measuring differences in urinary cell-free microRNA (miRNA) expression between patients with BC and those with hematuria. A multicenter study was performed using 543 urine samples obtained from the National Biobank of Korea, including 326 BC, 174 hematuria and 43 pyuria without cancer. The urinary miR-6124 to miR-4511 ratio was considerably higher in BC than in hematuria or pyuria, and enabled the discrimination of BC from patients with hematuria at a sensitivity of >90% (p < 0.001). Conclusively, the proposed noninvasive diagnostic tool based on the expression ratio of urinary cell-free miR-6124 to miR-4511 can reduce unnecessary cystoscopies in patients with hematuria undergoing evaluation for BC, with a minimal loss in sensitivity for detecting cancer.

    Original languageAmerican English
    Pages (from-to)380-388
    Number of pages9
    JournalInternational Journal of Cancer
    Issue number2
    StatePublished - Jan 15 2019

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research


    • bladder cancer
    • hematuria
    • miRNA
    • noninvasive biomarker


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