@article{c5c10d7e17934a6dbfc4860a0c2e3b0f,
title = "Urinary cell-free microRNA biomarker could discriminate bladder cancer from benign hematuria",
abstract = "The most common symptom of bladder cancer (BC) is hematuria. However, not all patients with hematuria are diagnosed with BC. Here, we explored a novel method to discriminate BC from hematuria under nonmalignant conditions by measuring differences in urinary cell-free microRNA (miRNA) expression between patients with BC and those with hematuria. A multicenter study was performed using 543 urine samples obtained from the National Biobank of Korea, including 326 BC, 174 hematuria and 43 pyuria without cancer. The urinary miR-6124 to miR-4511 ratio was considerably higher in BC than in hematuria or pyuria, and enabled the discrimination of BC from patients with hematuria at a sensitivity of >90% (p < 0.001). Conclusively, the proposed noninvasive diagnostic tool based on the expression ratio of urinary cell-free miR-6124 to miR-4511 can reduce unnecessary cystoscopies in patients with hematuria undergoing evaluation for BC, with a minimal loss in sensitivity for detecting cancer.",
keywords = "bladder cancer, hematuria, miRNA, noninvasive biomarker",
author = "Piao, {Xuan Mei} and Pildu Jeong and Kim, {Ye Hwan} and Byun, {Young Joon} and Yanjie Xu and Kang, {Ho Won} and Ha, {Yun Sok} and Kim, {Won Tae} and Lee, {Jong Young} and Woo, {Seung Hwo} and Kwon, {Tae Gyun} and Kim, {Isaac Y.} and Moon, {Sung Kwon} and Choi, {Yung Hyun} and Cha, {Eun Jong} and Yun, {Seok Joong} and Kim, {Wun Jae}",
note = "Funding Information: Key words: noninvasive biomarker, miRNA, bladder cancer, hematuria Abbreviations: AUC: area under the curve; BC: bladder cancer; MIBC: muscle invasive bladder cancer; miRNA: microRNA; NMIBC: nonmuscle invasive bladder cancer; ROC: receiver operating characteristics; RT-PCR: real-time polymerase chain reaction; VUC: Voided urine cytology Additional Supporting Information may be found in the online version of this article. Grant sponsor: International Science and Business Belt Program through the Ministry of Science, ICT and Future Planning ; Grant numbers: 2017K000490; Grant sponsor: Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education; Grant numbers: 2017R1D1A3B03031486; Grant sponsor: ChungBuk Bio-International Joint Research Support Project funded by ChungCheongBuk-Do ; Grant numbers: CB-BIO-2017-2-011 DOI: 10.1002/ijc.31849 History: Received 14 Jun 2018; Accepted 27 Aug 2018; Online 5 Sep 2018 Correspondence to: Wun-Jae Kim, Department of Urology, College of Medicine, Chungbuk National University, Chungdae-ro 1, Seowon-Gu, Cheongju, Chungbuk 28644, South Korea, Tel.: +82-043-269-6136, E-mail: wjkim@chungbuk.ac.kr Funding Information: Urine samples were provided by the Chungbuk National University Hospital and Kyungpook National University Hospital, members of the National Biobank of Korea, which is supported by the Ministry of Health, Welfare, and Family Affairs. Subjects were also obtained from Eulji University Hospital. All samples derived from the National Biobank of Korea were obtained with informed consent under Institutional Review Board-approved protocols. Funding Information: Urine samples were provided by the Chungbuk National University Hospital and Kyungpook National University Hospital, members of the National Bio-bank of Korea, which is supported by the Ministry of Health, Welfare, and Family Affairs. Subjects were also obtained from Eulji University Hospital. All samples derived from the National Biobank of Korea were obtained with informed consent under Institutional Review Board-approved protocols. Publisher Copyright: {\textcopyright} 2018 UICC",
year = "2019",
month = jan,
day = "15",
doi = "https://doi.org/10.1002/ijc.31849",
language = "American English",
volume = "144",
pages = "380--388",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "2",
}