Vascular Inflammation Risk Factors in Retinal Disease

Ileana Soto; Mark P. Krebs; Alaina M. Reagan; Gareth R. Howell

doi:https://doi.org/10.1146/annurev-vision-091517-034416

Vascular Inflammation Risk Factors in Retinal Disease

Ileana Soto, Mark P. Krebs, Alaina M. Reagan, Gareth R. Howell

Molecular and Cellular Biosciences

Rowan University

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Inflammation of the blood vessels that serve the central nervous system has been increasingly identified as an early and possibly initiating event among neurodegenerative conditions such as Alzheimer's disease and related dementias. However, the causal relevance of vascular inflammation to major retinal degenerative diseases is unresolved. Here, we describe how genetics, aging-Associated changes, and environmental factors contribute to vascular inflammation in age-related macular degeneration, diabetic retinopathy, and glaucoma. We highlight the importance of mouse models in studying the underlying mechanisms and possible treatments for these diseases. We conclude that data support vascular inflammation playing a central if not primary role in retinal degenerative diseases, and this association should be a focus of future research.

Original language	English (US)
Pages (from-to)	99-122
Number of pages	24
Journal	Annual Review of Vision Science
Volume	5
DOIs	https://doi.org/10.1146/annurev-vision-091517-034416
State	Published - Sep 15 2019

ASJC Scopus subject areas

Medicine(all)

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https://doi.org/10.1146/annurev-vision-091517-034416

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abstract = "Inflammation of the blood vessels that serve the central nervous system has been increasingly identified as an early and possibly initiating event among neurodegenerative conditions such as Alzheimer's disease and related dementias. However, the causal relevance of vascular inflammation to major retinal degenerative diseases is unresolved. Here, we describe how genetics, aging-Associated changes, and environmental factors contribute to vascular inflammation in age-related macular degeneration, diabetic retinopathy, and glaucoma. We highlight the importance of mouse models in studying the underlying mechanisms and possible treatments for these diseases. We conclude that data support vascular inflammation playing a central if not primary role in retinal degenerative diseases, and this association should be a focus of future research.",

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AB - Inflammation of the blood vessels that serve the central nervous system has been increasingly identified as an early and possibly initiating event among neurodegenerative conditions such as Alzheimer's disease and related dementias. However, the causal relevance of vascular inflammation to major retinal degenerative diseases is unresolved. Here, we describe how genetics, aging-Associated changes, and environmental factors contribute to vascular inflammation in age-related macular degeneration, diabetic retinopathy, and glaucoma. We highlight the importance of mouse models in studying the underlying mechanisms and possible treatments for these diseases. We conclude that data support vascular inflammation playing a central if not primary role in retinal degenerative diseases, and this association should be a focus of future research.

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Vascular Inflammation Risk Factors in Retinal Disease

Abstract

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