Viscosity sensitivity in a reversible polyacrylamide gel with DNA crosslinks

D. C. Lin, B. Yurke, N. A. Langrana

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations

Abstract

A polyacrylamide hydrogel in which double-stranded DNA replaces bis(acrylamide) as the crosslinker has been developed. The gel has the unique property of being reversible without heat; the addition of a removal DNA strand returns the gel to a liquid state by eliminating the crosslinks. Below a threshold concentration of crosslinks, the material behaves as a viscous liquid with a distinct melting temperature, above which viscosity decreases to a lower limit. At the threshold concentration of crosslinks, a solid gel forms at room temperature. Viscosity of the material is sensitive to both temperature and crosslinker density. This system possesses a large design space in comparison to conventional hydrogels due to the parameters introduced by the use of DNA crosslinks. Further characterization of the properties of the system is necessary to determine potential applications in drug delivery and tissue engineering.

Original languageEnglish (US)
Pages (from-to)627-628
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
StatePublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Keywords

  • DNA
  • Polyacrylamide
  • Tissue engineering
  • Viscosity

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