X-irradiation and the incorporation of precursors for salvage and de novo synthesis of DNA in hepatomas and liver

F. L. Khalil, M. A. Lea

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Abstract

The effect of X-irradiation 15 Gy (1500 rad) on precursor incorporation into DNA was studied in transplanted Morris hepatomas and liver of the tumor-bearing rats. Precursors were studied which are utilized by salvage mechanisms [3H]thymidine and ([3H]thymidine and [3H]deoxyuridine or in the novo synthesis of DNA ([14C]aspartate and [14C]formateP. The data suggested that salvage mechanisms are more sensitive to inhibition by X-irradiation and that DNA repair activity is greater in liver than hepatomas.

Original languageAmerican English
Pages (from-to)171-177
Number of pages7
JournalNeoplasma
Volume28
Issue number2
StatePublished - 1981

ASJC Scopus subject areas

  • Cancer Research

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