Zinc Lactate and Sapindin Act Synergistically with Lactocin 160 Against Gardnerella vaginalis

Yevgeniy Turovskiy, Michael L. Chikindas

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Lactocin 160 is a vaginal probiotic-derived bacteriocin shown to selectively inhibit the growth of Gardenerella vaginalis and some other pathogens commonly associated with bacterial vaginosis. The natural origin of this peptide, its safety, and selective antimicrobial properties make it a promising candidate for successful treatment and prophylaxis of bacterial vaginosis (BV). This study evaluated interactions between lactocin 160 and four other natural antimicrobials in the ability to inhibit G. vaginalis. We report that zinc lactate and soapnut extract act synergistically with lactocin 160 against this pathogen and therefore have a potential to be successfully used as the components of the multiple-hurdle antimicrobial formulation for the treatment of BV.

Original languageEnglish (US)
Pages (from-to)144-149
Number of pages6
JournalProbiotics and Antimicrobial Proteins
Volume3
Issue number2
DOIs
StatePublished - Jun 1 2011

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Microbiology

Keywords

  • Antimicrobial synergy
  • Bacteriocin
  • Natural antimicrobial

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